Psoriasis

Question 1

Psoriasis presents how?

Answer 1

Sharply Demarcated Erythematous Plaques with Scale

Question 2

Psoriasis is more common in?

Answer 2

Males

Question 3

What gene is affected in Psoriasis?

Answer 3

HLA-CW6 Chromosome 6

Question 4

What cell is affected in Psoriasis?

Answer 4

T Cell Adaptive immune keratinocytes with dermal dendritic cells

Question 5

What t cells are affected in psoriasis?

Answer 5

Th 1, 17 and 22

Question 6

VEGF in Psoriasis leads to?

Answer 6

Angiogenesis

Question 7

Interleukins and TNF Alpha in Psoriasis causes what?

Answer 7

Keratinocytes in psoriasis

Question 8

Cell Cycle in Psoriasis?

Answer 8

3-5 Days

Question 9

Cell cycle is normally?

Answer 9

28 Days

Question 10

What happens to nails in psoriasis?

Answer 10

Onycholysis, Pitting, Oil Spots

Question 11

Koebner Phenomenon presents in what condition?

Answer 11

Psoriasis

Question 12

Guttrate Psoriasis particularly affects?

Answer 12

Children and Adolescents due to Infection

Question 13

Diagnosis of Guttrate Psoriasis?

Answer 13

ASO Titre

Question 14

Pustular Psoriasis particularly affects?

Answer 14

Pregnant, Rapid Taper or Stop Steroids, Hypocalcaemia

Question 15

Erytherodermic Psoriasis is also called?

Answer 15

Red Man Syndrome >80% body surface covered

Question 16

How to manage psoriasis in primary care? (4)

Answer 16

Vit D3 Analogue
Coal Tar Creams
Topical Steroids
Salicyclic Acid

Question 17

Vit D3 Analogues do what?

Answer 17

Inhibit Epidermal Proliferation

Question 18

Secondary care treatment of Psoriasis? (5)

Answer 18

UVB Phototherapy
Oral Retinoids
Acitretin
Methotrexate
Ciclosporin

Question 19

What drug shouldn’t be used in Psoriasis in pregnant?

Answer 19

Oral Retinoids

Question 20

Which drug in Psoriasis has renal side effects?

Answer 20

Cyclosporin

Question 21

Biologics in Psoriasis affects what IL’s? (3)

Answer 21

12,17,23

Question 22

Biologics in Psoriasis are known as?

Answer 22

Anti TNF