Psoriasis Flashcards
Psoriasis presents how?
Sharply Demarcated Erythematous Plaques with Scale
Psoriasis is more common in?
Males
What gene is affected in Psoriasis?
HLA-CW6 Chromosome 6
What cell is affected in Psoriasis?
T Cell Adaptive immune keratinocytes with dermal dendritic cells
What t cells are affected in psoriasis?
Th 1, 17 and 22
VEGF in Psoriasis leads to?
Angiogenesis
Interleukins and TNF Alpha in Psoriasis causes what?
Keratinocytes in psoriasis
Cell Cycle in Psoriasis?
3-5 Days
Cell cycle is normally?
28 Days
What happens to nails in psoriasis?
Onycholysis, Pitting, Oil Spots
Koebner Phenomenon presents in what condition?
Psoriasis
Guttrate Psoriasis particularly affects?
Children and Adolescents due to Infection
Diagnosis of Guttrate Psoriasis?
ASO Titre
Pustular Psoriasis particularly affects?
Pregnant, Rapid Taper or Stop Steroids, Hypocalcaemia
Erytherodermic Psoriasis is also called?
Red Man Syndrome >80% body surface covered
How to manage psoriasis in primary care? (4)
Vit D3 Analogue
Coal Tar Creams
Topical Steroids
Salicyclic Acid
Vit D3 Analogues do what?
Inhibit Epidermal Proliferation
Secondary care treatment of Psoriasis? (5)
UVB Phototherapy Oral Retinoids Acitretin Methotrexate Ciclosporin
What drug shouldn’t be used in Psoriasis in pregnant?
Oral Retinoids
Which drug in Psoriasis has renal side effects?
Cyclosporin
Biologics in Psoriasis affects what IL’s? (3)
12,17,23
Biologics in Psoriasis are known as?
Anti TNF
