PRR Families Flashcards
How are a wide variety of PAMP ligands recognized?
families of PRRs
What are the 5 main PRR families?
TLR/ CLR/ NLR/ RLR/ ALR
what happens when PRRs bind to PAMPs?
signalling pathways initiated- contributing to innate/ inflammatory responses
Where are TLRs located?
Plasma membrane/ membranes of endosomes/ lysosomes
What is a component of the TLR exterior domain?
LRR = leucine-rich repeats
What is the interior domain of TLR called?
TIR domain = toll interleukin receptor
What happens after ligand binds to TLR exterior domain?
ligand (PAMP/ DAMP) induced TLR dimerization
How many TLRs are there?
13
What are dimers with extracellular leucine-rich domains that bind PAMPS/ DAMPS?
TLRs
Since TLRs recognize many different pathogens, what determines what each TLR will bind?
= location
extracellular ligands- PM
ligands released by endocytosed microbes- endosomes/ lysosomes
What is the ligand of TLR2?
peptidoglycan
What microbe would peptidoglycan be on?
gram-positive bacteria
What is the ligand of TLR3?
double-stranded RNA
What microbe is double-stranded RNA on?
viruses
What is the ligand of TLR4?
Lipopolysaccharide
What is the microbe target of TLR4?
gram-negative bacteria (lipopolysaccharide)
What is the ligand of TLR5?
Flagellin
What microbe is flagellin on?
bacteria
What microbe is lipopolysaccharide on?
gram-negative bacteria
What does TLR binding of PAMP activate?
signalling pathways
Where are adaptor proteins recruited to by the different TLRs?
Toll/IL-1R = TIR domain