Antimicrobials

Question 1

What barriers exist to prevent pathogen entry to host?

Answer 1

physical/ chemical

Question 2

How does the innate immune system recognize pathogens?

Answer 2

PAMPs

Question 3

How are dead/ damaged self-structures recognized?

Answer 3

DAMPs

Question 4

What receptors recognize DAMPs?

Answer 4

PRR pattern recognition receptor

Question 5

What epithelial barriers prevent pathogen entry into body’s interior?

Answer 5

skin/ mucosal membranes

Question 6

What substances are produced by epithelial barriers?

Answer 6

acidic pH/ enzymes/ antimicrobial proteins+ peptides

Question 7

What are 3 antimicrobial proteins?

Answer 7

Lysozyme/ Lactoferrin/ Surfactant proteins

Question 8

Where are lysozymes/ lactoferrins located?

Answer 8

mucosal (mouth)/ glandular secretions

Question 9

What antimicrobial protein cleaves glycosidic bonds of peptidoglycan in bacterial cell walls? (cell lysis)

Answer 9

Lysozyme

Question 10

What antimicrobial protein binds/ sequesters Iron- limiting microbial growth?

Answer 10

Lactoferrin

Question 11

What antimicrobial protein blocks bacterial surface components in respiratory tract secretions?

Answer 11

Surfactant proteins

Question 12

What are 3 antimicrobial peptides?

Answer 12

Defensins/ Histatins/ Dermcidin

Question 13

What antimicrobial peptide disrupts membranes of microbes?

Answer 13

Defensins

Question 14

What antimicrobial peptide involves lectins that bind to fungal cell walls/ enter cytoplasm with harmful effects?

Answer 14

Histatins