Proteins, Metabolism Flashcards
are used for anabolic purposes such as synthesis of nonessential amino acids, tissue protein synthesis, enzyme or hormone synthesis, deamination, or transamination.
Absorbed proteins
Amino acid synthesis and degradation are brought about by two reactions called ? that occur in the liver.
transamination and deamination
is the major site of amino acid metabolism
liver
is responsible for nonessential amino acid synthesis
transaminases
The liver has enzymes such as transaminases and is responsible for nonessential amino acid synthesis through a process called
transamination
An amino group from one amino acid is transferred to an ? to form a new amino acid
organic acid
is needed for transaminase activity (transamination)
Vitamin B6 (pyridoxine)
Transamination also provides a link between?
Transamination also provides a link between protein and carbohydrate metabolism, where certain amino acids can use their C skeleton for?
glucose synthesis
is the removal of amino groups from amino acids to form ammonia
Deamination
deamination needed for getting rid of nitrogen from the animal’s body
After deamination or transamination, this part of amino acid are left and are used for making glucose, ketone bodies, or energy production.
C skeleton
is a chemical reaction that transfers an amino group to a keto acid to form new amino acids.
Transamination
All amino acids, except ?, are glucogenic, meaning that they can use the C skeleton for glucose synthesis.
leucine and lysine
are strictly ketogenic amino acids (forms ketone bodies) and can provide acetyl CoA as an energy source.
Leucine and lysine
Since both carbons of acetyl CoA are lost in the tricarboxylic acid (TCA) cycle, it cannot provide?
glucose
is liberated from amino acid degradation is toxic to the central nervous and needs to be excreted or detoxified.
ammonia
Most mammals detoxify ammonia and excrete it as ? in the urine
urea
birds excrete ammonia as?
uric acid
Detoxification of ammonia to urea is through the?
urea cycle
The detoxification of ammonia to form urea is brought about by the urea cycle through two tissues?
liver and kidney
Two nonprotein amino acids involved in the urea cycle are?
ornithine and citrulline
The first step in the urea cycle is the formation of?
carbamoyl phosphate
What reacts with a compound called carbamoyl phosphate and forms citrulline.
Ornithine
Ornithine reacts with a compound called carbamoyl phosphate and forms?
citrulline