Proteins Flashcards
For Proteins to function they require quartiary structrue? True or false
False, only requires tertiary
What is the central dogma
Transcription and translation to proteins
What base swapped out for urial in RNA
Tyrosine
Do amino acids exist in L or D configuration biologically
L
At ph 7 the amino acid is a _______
Zwitteron, COO- and NH3 postitvev
When amino acid in in low ph, it is a ……
Cation, gains H on carboxylic acid group
When amino acid is in high ph it becomes ……
Anion, losses H on carboxylic acid and amino group
Name the 6 amino acid groups and give example of each
Aliphatic - glycine and valine (hydrocarbon chain) Aromatic- phenylalanine Sulphur contains group- methanione Acidic or basic - aspartate and lysine Polar Miscellaneous - proline
Porins is composed of what type of secondary structure
Beta sheets
What type of bonding is required for secondary structure
Hydrogen bonding between amino and carboxylic acid group
What type of bonding is required for tertiary
All types of bonds, and it’s between R groups
What is quaternary structure
When multiple polypeptides come together *some proteins only have one poplyppetide therefore not all require quaternary
During denaturation the primary structure is rarely broken, true or false ?
True, too much energy to break peptide bonds, and if tertiary is lost the protein won’t function
When can conjugation of parts onto proteins occur
Post translational Co translational (during
The proteins in the blood have olligosacchrides coming off them allowing blood typing to occur for protection. What type of protein is this
Glycoproteins
What is the name of protein with lipids on them
Lipoproteins
What is a protein called with metal in them
Metalloprotease
What is the mutation in sickle cell aemia, and what does this effect
Glycine to valine, alters tertiary structure which in turn changes the quaternary. haem groups stick together
Proteins can be based on both structure and function. What are the 3 functional classes
Fibrous , globular and membranous
If I have increased antibodies (globular proteins) what disease may this be caused by
Myaloma
How is scurvy caused
Lack of vitamin c means unable to produce collagen (fibrous protein)
What disease is caused by mutation in LDL receptor which prevents chloestoral uptake into the cell
Familial hyperchloesterolamoia
Amino acids have a acidic and basic group, what is the term for this
Amphoteric
Formation of a dipeptide occurs from condensation reaction, true or false
True, H20 is produced
What is the strongest bond in a protein: A) ionic B) hydrogen C van der waals D) disulphides bonds
D) Disulphides bonds
Between two cysteine residues
What type of bond is cleaved in the inactive insulin to produce a active insulin
Disulphide bone
