Proteins

Question 1

For Proteins to function they require quartiary structrue? True or false

Answer 1

False, only requires tertiary

Question 2

What is the central dogma

Answer 2

Transcription and translation to proteins

Question 3

What base swapped out for urial in RNA

Answer 3

Tyrosine

Question 4

Do amino acids exist in L or D configuration biologically

Answer 4

L

Question 5

At ph 7 the amino acid is a _______

Answer 5

Zwitteron, COO- and NH3 postitvev

Question 6

When amino acid in in low ph, it is a ……

Answer 6

Cation, gains H on carboxylic acid group

Question 7

When amino acid is in high ph it becomes ……

Answer 7

Anion, losses H on carboxylic acid and amino group

Question 8

Name the 6 amino acid groups and give example of each

Answer 8

Aliphatic - glycine and valine (hydrocarbon chain)
Aromatic- phenylalanine 
Sulphur contains group- methanione 
Acidic or basic - aspartate and lysine
Polar 
Miscellaneous - proline

Question 9

Porins is composed of what type of secondary structure

Answer 9

Beta sheets

Question 10

What type of bonding is required for secondary structure

Answer 10

Hydrogen bonding between amino and carboxylic acid group

Question 11

What type of bonding is required for tertiary

Answer 11

All types of bonds, and it’s between R groups

Question 12

What is quaternary structure

Answer 12

When multiple polypeptides come together *some proteins only have one poplyppetide therefore not all require quaternary

Question 13

During denaturation the primary structure is rarely broken, true or false ?

Answer 13

True, too much energy to break peptide bonds, and if tertiary is lost the protein won’t function

Question 14

When can conjugation of parts onto proteins occur

Answer 14

Post translational
Co translational (during

Question 15

The proteins in the blood have olligosacchrides coming off them allowing blood typing to occur for protection. What type of protein is this

Answer 15

Glycoproteins

Question 16

What is the name of protein with lipids on them

Answer 16

Lipoproteins

Question 17

What is a protein called with metal in them

Answer 17

Metalloprotease

Question 18

What is the mutation in sickle cell aemia, and what does this effect

Answer 18

Glycine to valine, alters tertiary structure which in turn changes the quaternary. haem groups stick together

Question 19

Proteins can be based on both structure and function. What are the 3 functional classes

Answer 19

Fibrous , globular and membranous

Question 20

If I have increased antibodies (globular proteins) what disease may this be caused by

Answer 20

Myaloma

Question 21

How is scurvy caused

Answer 21

Lack of vitamin c means unable to produce collagen (fibrous protein)

Question 22

What disease is caused by mutation in LDL receptor which prevents chloestoral uptake into the cell

Answer 22

Familial hyperchloesterolamoia

Question 23

Amino acids have a acidic and basic group, what is the term for this

Answer 23

Amphoteric

Question 24

Formation of a dipeptide occurs from condensation reaction, true or false

Answer 24

True, H20 is produced

Question 25

What is the strongest bond in a protein:
A) ionic 
B) hydrogen 
C van der waals
D) disulphides bonds

Answer 25

D) Disulphides bonds

Between two cysteine residues

Question 26

What type of bond is cleaved in the inactive insulin to produce a active insulin

Answer 26

Disulphide bone