Essential Pharma

Question 1

Name the 4 different cell surface receptors

Answer 1

Channel/ iononotrophic
G protein coupled, metabotrophic
Receptor enzymes
Integrine enzymes

Question 2

Describe the pathway when adenyl cyclase (metabotrophic receptor) is activated

Answer 2

ATP activates cAMP, Which activates protein kinase A which phosphorylates protein

Question 3

Describe the pathway when PLC (metabotrophic enzyme) is activated

Answer 3

Plc when activated, activates IP3 and DAG.
IP3 then causes calcium to be release =cell response
DAG then activates protein kinase A, phosphorylation of proteins = cell response

Question 4

How might calcium release be stimulated from SR

Answer 4

1) IP3

2) trickles of Ca let in by DLP calcium channels in transverse tables in muscle

Question 5

Define efficacy and affinity

Answer 5

Affinity is how likely a drug will bind to a target

Efficacy is how good the drug is at activating the receptor

Question 6

What is the EC50 of a drug and how does this relate to affinity

Answer 6

Conc of drug which is required to get the max response. High EC50 will mean high affinity

Question 7

Vmax will increase if efficacy is high, true or false

Answer 7

True,

Question 8

What does it mean if an agonist or antagonist is selective

Answer 8

Means it only works for specific receptors