protein synthesis inhibitors

Question 1

Chloramphenicol binds reversibly to which subunit

Answer 1

50S

Question 2

Tetracyclines bind reversibly to which subunit

Answer 2

30S

Question 3

Inhibits peptide bond formation

Answer 3

Chloramphenicol

Question 4

Prevents addition of amino acids to the growing peptide
Blocks binding of aminoacyl-tRNA to the acceptor site of the mRNA ribosome complex

Answer 4

Tetracyclines

Question 5

Protein synthesis inhibitors active against chlamydia

Answer 5

Tetracyclines (Tigecycline, Eravacycline, Omadacycline)
Macrolides (Erythromycin, Azithromycin)

Question 6

CAP, Syphilis, Leptospirosis, Acne, Lyme disease, Malaria prophylaxis, Amoebiasis

Answer 6

Doxycycline

Question 7

Gastrointestinal ulcers caused by H. pylori

Answer 7

Tetracycline

Question 8

Meningococcal carrier state

Answer 8

Minocycline

Question 9

Inhibits renal actions of ADH (non microbial func)

Answer 9

Demeclocycline

Question 10

Active against CONS, MRSA strains, VRE strains
Strep, Entero, gram (+) rods, Acinetobacter sp., anaerobes, Rickettsiae, Chlamydia sp., L. pneumophila, mycobacteria

Answer 10

Tigecycline, Eravacycline, Omadacycline

Question 11

3rd line drug for TB

Answer 11

Tetracyclines

Question 12

Penetrates Placenta and BBB

Answer 12

Chloramphenicol

Question 13

Crosses placental barrier and is excreted in breast milk

Answer 13

Tetracyclines

Question 14

Absorption impaired by multivalent cations (Ca, Mg, Fe, Al), dairy products, antacids, and alkaline pH

Answer 14

Tetracyclines

Question 15

Tetracyclines eliminated nonrenally

Answer 15

Doxycycline and Tigecycline

Question 16

Tetracyclines given IV

Answer 16

Tigecycline and Eravacycline

Question 17

Bone marrow toxicity
Inhibition of RBC maturation
Aplastic Anemia
Gray Baby Syndrome

Answer 17

Chloramphenicol

Question 18

Tooth enamel dysplasia
Irregularities in bone growth
Crown deformation (permanent teeth)
Fanconi syndrome

Answer 18

Tetracyclines

Question 19

Photosensitivity

Answer 19

Demeclocycline

Question 20

Vestibular toxicity

Answer 20

Doxycycline and Minocycline

Question 21

Macrolides and Clindamycin bind to which subunit

Answer 21

50S

Question 22

Backup drug for MRSA

Answer 22

Clindamycin

Question 23

Toxic shock syndrome

Answer 23

Clindamycin + Penicillin G

Question 24

Necrotizing fasciitis

Answer 24

Clindamycin

Question 25

Penetrating wounds to the abdomen and gut

Answer 25

Clindamycin + Aminoglycoside or cephalosporin

Question 26

Prophylaxis of endocarditis in valvular disease Pelvic, lung, and periodontal abscesses

Answer 26

Clindamycin

Question 27

PJP in Aids

Answer 27

Clindamycin + Primaquine

Question 28

AIDS-related toxoplasmosis

Answer 28

Clindamycin + Pyrimethamine

Question 29

Dosage reduction is recommended for patients with creatinine clearances less than 30 mL/min

Answer 29

Clarithromycin

Question 30

Torsades de pointes arrhythmia

Answer 30

Macrolides

Question 31

Traverses the placenta and reaches the fetus but cannot enter BBB

Answer 31

Erythromycin

Question 32

Penetrates into most tissues and phagocytic cells extremely well except for CSF

Answer 32

Azithromycin

Question 33

Acute Cholestatic Hepatitis

Answer 33

Erythromycin

Question 34

Pseudomembranous colitis

Answer 34

Clindamycin

Question 35

Streptogramins and Lefamulin bind to which subunit

Answer 35

50S

Question 36

Linezolid binds to which subunit

Answer 36

23S ribosomal RNA of the 50S subunit

Question 37

Linezolid MOA

Answer 37

Prevents the formation of ribosome complex that initiates protein synthesis

Question 38

Lefamulin MOA

Answer 38

Inhibits bacterial protein synthesis Binding pocket closes around drug molecule, preventing tRNA from binding

Question 39

Protein synthesis inhibitors with MRSA activity

Answer 39

Tedizolid Quinupristin-Dalfopristin

Question 40

Protein synthesis inhibitor active against gonorrhea

Answer 40

Lefamulin

Question 41

Primarily eliminated in feces

Answer 41

Quinupristin-Dalfopristin

Question 42

Arthralgia-myalgia

Answer 42

Quinupristin-Dalfopristin

Question 43

Treatment of VRE infections, HCAP, CAP, skin and soft tissue infections, **MDR-TB** and Nocardia infections

Answer 43

Linezolid

Question 44

Oxazolidinone that is 100% bioavailable

Answer 44

Linezolid

Question 45

Thrombocytopenia Anemia Neutropenia Optic and peripheral neuropathy Lactic acidosis Serotonin syndrome

Answer 45

Linezolid

Question 46

Oxazolidinone for skin and soft tissue infection

Answer 46

Tedizolid

Question 47

Which is higher protein binding: Linezolid or Tedizolid

Answer 47

Tedizolid (70%-90%)

Question 48

For CAP and lower respiratory tract infections

Answer 48

Lefamulin

Question 49

Protein synthesis inhibitor active against Lower respi infections, Atypical pathogens, Aerobic gram (+) and STI's

Answer 49

Lefamulin

Question 50

Causes congenital malformations

Answer 50

Lefamulin

Question 51

Protein synthesis inhibitor that requires dose adjustments

Answer 51

Lefamulin