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pcol > aminoglycosides > Flashcards

aminoglycosides Flashcards

1
Q

Killing action will remain even if conc is below MIC
Single dosing

A

Concentration-dependent

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2
Q

Should consistently be at or above MIC
Multiple dosing

A

Time-dependent

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3
Q

Concentration-dependent or Time-dependent:
Aminoglycosides

A

Concentration-dependent

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4
Q

Concentration-dependent or Time-dependent:
Penicillin, Cephalosporins

A

Time-dependent

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5
Q

Peak serum levels

A

30-60 mins after administration

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6
Q

Trough serum levels

A

Just before the next dose

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7
Q

Irreversible inhibitors of protein synthesis

A

Aminoglycosides

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8
Q

Aminoglycosides bind to which subunit

A

30S

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9
Q

Aminoglycosides exhibit synergism with which class of antimicrobials

A

Cell wall synthesis inhibitors

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10
Q

MOA of aminoglycosides

A

Block formation of initiation complex
Cause misreading of the mRNA template codes
Inhibit translocation

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11
Q

Used for serious infections caused by aerobic gram (-) bacteria
E. coli, Klebsiella, Providencia, Serratia, Enterobacter, Proteus, Pseudomonas

A

Gentamicin, Tobramycin, Amikacin

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12
Q

Has antipseudomonal activity

A

Gentamicin, Tobramycin, Amikacin

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13
Q

2nd line for TB

A

Streptomycin

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14
Q

Decreases patient ammonia load by killing gut pets to inhibit bacterial metabolism and reduce ammonia production

A

Neomycin

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15
Q

Topical aminoglycoside

A

Neomycin

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16
Q

For serious infections resistant to other aminoglycosides
Last line of drug

A

Netilmicin

17
Q

IM as a single dose for gonorrhea
Effective for urethritis only not pharyngeal

A

Spectinomycin

18
Q

Ototoxicity: Auditory impairment

A

Amikacin and Kanamycin

19
Q

Ototoxicity: Vestibular dysfunction

A

Gentamicin and Tobramycin

20
Q

Most nephrotoxic

A

Gentamicin and Tobramycin

21
Q

Reversible nephrotoxic effect of aminoglycosides

A

Acute tubular necrosis

22
Q

Nephrotoxicity is increased with the use of what drugs

A

Loop diuretics

23
Q

Treatment for neuromuscular blockade and respiratory paralysis caused by aminoglycosides

A

Calcium
Neostigmine
Ventilatory support

24
Q

True or False: Aminoglycosides do not readily cross BBB

A

True, unless patient is a neonate

25
Q

Aminoglycoside excretion is directly proportional to what

A

Creatinine clearance

pcol (6 decks)

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