Protein Structure and Function pt 2

Question 1

What is the #1 problem in Anemia of Chronic Dz?

Answer 1

RBCs die faster

Question 2

What role does Hepcidin play?

Answer 2

it interferes with transferrin’s ability to absorb iron

Question 3

What happens to the bone marrow in ACD?

Answer 3

BM is turned off to save energy at about 3 wks

Question 4

What lab is important to look at in Anemia of Chronic Dz ?

Answer 4

FERRITIN! It will be high.

Question 5

BAL is used to chelate?

Answer 5

Lead and Arsenic

Question 6

Penicillamine is used to chelate?

Answer 6

Copper and Lead

Question 7

At what levels of lead do you notify the public health department?

Answer 7

15-44ug/dl

Question 8

What is the tx of lead poisoning?

Answer 8

Succimer aka DMSA

Question 9

Lead poisoning can cause what effect in children?

Answer 9

delayed language development and irreversible neurobehavioral dysfunction

Question 10

EDTA treatment causes what deficiency ?

Answer 10

On anything with a 2+ charge

Question 11

MCC of mental retardation in children

Answer 11

Fetal alcohol syndrome
Fragile X
Down’s syndrome

Question 12

What is the enzyme deficiency of porphyria cutanea tarda ?

Answer 12

uroporphyrinogen decarboxylase

Question 13

What is the tx of porphyria cutanea tarda?

Answer 13

protect from light; use red, blue lights
blood transfuse bc of hemolytic anemia
phlebotomy
anti-malarias

Question 14

Most common porphyria?

Answer 14

(AIP) Acute intermittent porphyria

Question 15

What is the enzyme deficiency of acute intermittent porphyria?

Answer 15

uroporphyrinogen I synthase aka porphobilinogen deaminase aka uroporphyrinogen decarboyxylase

Question 16

What is the short and long term treatment of acute intermittent porphyria?

Answer 16

Glucose is the short term tx to help excrete faster and Hematin is the long term tx decrease synthesis of porphyrins rings