GI Physio

Question 1

Type 1

Answer 1

increased Chylomicrons bc LPL deficiency in liver

Question 2

Type 2A

Answer 2

increased LDL bc downregulation of 90% of LDL receptor (obesity)

Question 3

Type 3

Answer 3

increased IDL bc ApoE problem (HDL)

Question 4

Type 4

Answer 4

increased VLDL bc LPL at adipose tissue deficiency

Question 5

Type 5

Answer 5

increased VLDL and Chylomicrons bc C2 deficiency (HDL)

MC in Diabetics

Question 6

Type 2B (MOST COMMON)

Answer 6

increased VLDL and LDL bc there is LPL and C2 deficiency at adipose tissue

Obesity downregulates

Question 7

Fibrates MOA

Answer 7

activates PPAR alpha which increases LPL activity leading to decrease TG and hepatic VLDL

Question 8

Probucol MOA

Answer 8

inhibit cholesterol synthesis by decreasing absorption and increasing LDL breakdown

Question 9

Bile Acid Resins (Cholestyramine and Colestipol) MOA

Answer 9

Bind up bile salts and pulls out CHO for excretion

Question 10

Heavy Chain Disease

Answer 10

IgA producing plasma cells
B cells in the ileum lymph nodes
MM of the bowel wall

Question 11

Retroperitoneal structures

Answer 11

Suprarenal 
Aorta
Duodenum (2nd-4th)
Pancreas (no tail)
Ureters
Colon
Kidneys
Esophagus 
Rectum

Question 12

PCSK9 inhibitors

Answer 12

monoclonal antibodies that reduce LDL receptor degradation.

Question 13

Ezetimibe

Answer 13

blocks intestinal CHO absorption