protein Structure Flashcards
exam 1
compromise aa residues which fold to adopt a unique structure and function
proteins
interior of water soluble proteins are ______ and aa residues with ________ are favored
non-polar and aa residues with hydrocarbon-rich side chain
exterior of water soluble proteins are _______ and aa residues with _______ side chains or ________ are predominant here
exterior is polar and aa residues with charged side chains and hydrophilic molecules are predominant
fits poorly into helices
proline
absorb UV light
tyrosine and tryptophan
mutations may disrupt function by altering a ______ ____ or _____ ___
altering a critical contact or altering structure
small aa that allows close approach of one part of a protein to another
glycine
multiple domains, binds nucleotides with ATP and spans membrane and allow chloride transport
CFTR
relatively insoluble in water and are elongated instead of being compact
fibrous protein
contains a demosine cross-link
elastin
desmosine cross link formed by
lysine residues
protein of hair and nails and skin and is very helical
keratin
maximum buffering
when the [base]=[acid] at the pKA
true or false: closer to pKA, buffering is pooer
false
major buffers (3)
bicarbonate
phosphate
proteins
molecules that pass through membrane poorly
charged
point where pH is net charge is zero
isoelectric point
controlled by breathing and affects the blood, pka is a little lower than neutral
bicarbonate
found in cells, pka is near neutrality pH 7
phosphate
found in blood and in cells; has a wide variety of different side chains at a variety of pKa values
proteins
