protein hemoglobin and myoglobin part 1 Flashcards
where is myoglobin located
in the muscle
where is hemoglobin located
in red blood cells
how many subunits does hemoglobin have
4 homologous Mb like subunits
what was the first protein whose 3d structure was determined by x ray crystallography
myoglobin
how many helices does myoglobin have
8 alpha helices labeled A through H
what is myolglobin
a monomer
what is hemoglobin
a tetramer
how many alpha and beta subunits does hemoglobin have
2 alpha and 2 beta
who solved Hb’s structure
Max perutz
what is a heme made of
protoporphyrin IX + Fe+2
what do Mb and Hb’s 4 subunits contain
a heme prosthetic group
what is heme prosthetic group
non amino acid portion of a protein that is required for biological activity
what is the octahedral coordination complex
the O2 binding pocket in heme
what amino acid is involved in the octahedral coordination complex
His F8
what does His E7 do in O2 binding pocket in heme
forces any ligand binding to Fe(II) to bind at a bent angle
