gluconeogenesis Flashcards
what is the breaking up meaning of gluco-neo-genesis
synthesis of new glucose
what is glucogeogenesis
metabolic pathway that generates glucose from non carbohydrate carbon substrates like lactate, pyruvate
why do we use gluconeogenesis
brain and central nervous system use glucose as their sole energy
what is the reversal of glycolysis
gluconeogenesis
what steps do glycolysis and glucogenesis have in common
hexokinase–> G6P
pfk 1 –> Fructose 1,6-bisphosphate
PK—> pyru. carbox. and pep carboxylase
what is similar to hexokinase in gluconeogenesis
glucokinase, isozyme of glycolysis in liver
to bypass pyruvate kinase what two enzymes are involved
pyruvate carboxylase and PEPCK
what does pyruvate carboxylase do
catalyzes the atp and biotin dependent conversionof pyruv. oxaloacetate in the mitochondrial matrix
what does PEPCK
uses gtp to convert oxaloacetate to phosphoenolpyruvate by phosphorylation
pyruvate carb. uses what cofactor
biotin and it involves CO2
what is the net atp. gtp, atp, NADH in gluconeo
2 atp
2Gtp = atp equivalent
2 ATP
2 nAdh
where does gluconeogenesis happen
90% in the liver
what bypasses glucokinase
glucose 6 phosphate
why is the liver important
huge reservoir or buffer for glucose
glucokinase never achieves equilibirrum
where do the reactions happen
in the cytosol except pyruvate carboxylase and some pep carb. happen in the mitochondria matrix
