Protein Folding Flashcards
What is the secondary sequence of a protein?
Local spacial arrangement (eg. a-helix)
What is the tertiary sequence of a protein?
3D arrangement of all atoms
What is the quaternary sequence of a protein?
3D arrangement of protein subunits
What type of bonds hold the primary sequence together?
Covalent bonds
How long is each turn (pitch) of the alpha helix coil?
0.54nm
How many amino acids are in each pitch?
3.6
What type of bonds form between the chain links to maintain the alpha helix structure?
Hydrogen bonds
Name two amino acids that act as alpha-helix breakers
Pro- makes rotation impossible
Gly- the small R group works better in other structures
What does a B-strand look like?
The chain is fully extended
What is the distance between adjacent amino acids?
0.35nm
How do the R groups lie in a B-strand?
Alternate on opposite sides of the chain
What happens when multiple B-strands lie anti-parallel to each other?
A B-sheet forms
Name 3 functions of a fibrous protein
Support, shape, protection
Name 2 functions of a globular protein
Catalysis, Regulation
What is a protein domain?
Part of the polypeptide chain that folds into a distinct shape with often a specific functional role.
