Blood Clotting

Question 1

When does the extrinsic blood clotting pathway occur?

Answer 1

Trauma- vascular damage

Question 2

What is a fibrin clot?

Answer 2

A mesh like structure around RBCs

Question 3

What is the first molecule to be released in the extrinsic pathway?

Answer 3

Factor III

Question 4

Which part of factor IX and factor X target it to the membranes?

Answer 4

Gla domains

Question 5

What is the function of a Kringle domain in prothrombin?

Answer 5

Keep prothrombin in the inactive form

Question 6

What is fibrinogen made up of?

Answer 6

2 sets of tripeptides. The tripeptides are alpha, beta and gamma

Question 7

What do multiple cleaved fibrinogen molecules form?

Answer 7

A soft clot

Question 8

Which factor is defective in Haemophilia A and how does this effect the body?

Answer 8

Factor VIII- slower clotting

Question 9

What molecule aids fibrinolysis?

Answer 9

Plasminogen (inactive) which becomes plasmin

Question 10

When does the intrinsic blood clotting pathway occur?

Answer 10

Damaged endothelial lining of blood cells