Protein C Deficiency Flashcards
1
Q
Protein C Deficiency
A
Protein C Deficiency is an autosomal co-dominant condition which causes an increased risk of THROMBOSIS
Features:
- VTE
- Skin necrosis following commencement of Warfarin; when warfarin is first started biosynthesis of protein C is reduced
> Results in temporary procoagulant state after initially starting warfarin, normally avoid by concurrent heparin administration
Thrombosis may occur in venues > Skin necrosis
