Blood Films

Question 1

TARGET CELLS

Answer 1

SEEN IN:
Sickle-cell/thalassaemia
Iron-deficiency anaemia
Hyposplenism
Liver disease

Question 2

‘TEAR-DROP’ POIKILOCYTES

Answer 2

SEEN IN Myelofibrosis

Question 3

SPHEROCYTES

Answer 3

SEEN IN:
Hereditary spherocytosis
Autoimmune hemolytic anaemia

Question 4

BASOPHILIC STIPPLING

Answer 4

SEEN IN:
Lead poisoning
Thalassaemia
Sideroblastic anemia
Myelodysplasia

Question 5

HOWELL-JOLLY BODIES

Answer 5

SEEN IN Hyposplenism (seen in Coeliac)

Question 6

HEINZ BODIES

Answer 6

SEEN IN:
G6PD deficiency
Alpha-thalassaemia

Question 7

SCHISTOCYTES (‘Helmet cells’)

Answer 7

SEEN IN:
Intravascular haemolysis
Mechanical heart valve
Disseminated intravascular coagulation

Question 8

‘PENCIL’ POIKILOCYTES

Answer 8

SEEN IN Iron Deficiency Anaemia

Question 9

BURR CELLS (ECHINOCYTES)

Answer 9

SEEN IN:
Uraemia
Pyruvate kinase deficiency

Question 10

ACANTHOCYTES

Answer 10

SEEN IN Abetalipoproteinemia, Hyposplenism

Question 11

HYPERSEGMENTED NEUTROPHILS

Answer 11

SEEN IN Megaloblastic Anaemia - VIT B12 Deficiency

Question 12

Hyposplenism eg post-splenectomy

Answer 12

Target cells
Howell-Jolly bodies
Pappenheimer bodies
Siderotic granules
Acanthocytes

Question 13

IDA

Answer 13

Target cells
‘Pencil poikilocytes’
If combined with B12/Folate deficiency = DIMORPHIC FILM - mixed microcytic + macrocytic

Question 14

Myelofibrosis

Answer 14

Tear Drop poikilocytes

Question 15

Intravascular Haemolysis

Answer 15

Schistocytes

Question 16

Megaloblastic Anaemia

Answer 16

Hypersegmented neutrophils

Question 17

Coeliac Disease

Answer 17

Howell-Jolly bodies (Hyposplenism)

Pencil poikilocytes (IDA)

Both features of Coeliac disease!

Question 18

ATYPICAL LYMPHOCYTES

Answer 18

Glandular Fever

Infectious Mononucleosis

Question 19

Blood Film of AML

Answer 19

Myeloid blasts

Auer rods

Question 20

Myelodysplasia Blood Film

Answer 20

Myelodysplasia typically results in red cells of abnormal shapes (poikilocytosis) and sizes (anisocytosis) with Pappenheimer bodies (abnormal granules of iron).