Protease inhibitors Flashcards

1
Q

What drug agents make up the protease inhibitor group?

A
  • Lopinavir
  • Atazanavir (used when lopinavir is not welll tolerated)
  • Darunavir
  • Saquinavir
  • Ritonavir ( acts as a booster- 100 ml dose increase concentration of the other protease inhibitors-reducing the pill burden)
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2
Q

What’s the administration route of protease inhibitors?

A
  • Oral route

*They’re well absorbed with food.

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3
Q

Any CSF penetration?

A

No, poor

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4
Q

What’s the metabolic pathway of protease inhibitors?

A

Cytochrome P450

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5
Q

What’s are the side effects of using Atazanavir (ATV)?

A
  • Jaundice
  • gall stones
  • nephrotoxicity
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6
Q

What’s are the side effects of using Lopinavir?

A
  • GI disturbance (hyperglycaemia)
  • Lipid disturbances (dyslipidemia)
  • atherosclerosis
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7
Q

What’s are the side effects of using Darunavir?

A
  • Glucose intolerance
  • Rash
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8
Q

Which 2 protease inhibitors interact with warfarin? What are the outcomes from this?

A

Atazanavir and Darunavir

*They both decrease International Normalised Ratio of wafarin (INR)
-Meaning they decrease warfarin levels in blood and result in clot formation)

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9
Q

A protease inhibitor that prolongs the QT and PR intervals

A

Saquinavir

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