Prostaglandins

Question 1

Eicosanoids

Answer 1

Prostaglandins and their related compounds

potent; wide range of physiologic responses

Question 2

Procoagulant

Answer 2

platelets make thromboxane that makes platelets aggregate and vasoconstriction

Question 3

Anticoagulant

Answer 3

vascular endothelial cells make prostacyclin that inhibits platelet aggregation and stims vasodilation

Question 4

Arachidonic Acid

Answer 4

precursor for most eicosanoids
made from linoleic acid (FA)
stored on phospholipids
released by phospholipase (A2)

Question 5

Lipoxygenase

Answer 5

enzyme that synthesizes leukotrienes

Question 6

Cyclooxygenase

Answer 6

enzyme that makes prostacyclin and thromboxanes

Question 7

Glucocorticoids

Answer 7

steroidal anti-inflammatory drug- especially for asthma
promotes up-regulatioon of phospholipase A2 inhibitor
down-regulate COX-2

Question 8

Where do steroids act?

Answer 8

gene level

Question 9

NSAIDs

Aspirin

Answer 9

Inhibit COX step

no prostacyclins and thromboxanes made

Question 10

Aspirin Mechanism

Answer 10

irreversibly inactivates COX by acetylation

suicide inhibitor

Question 11

Aspirin effect on Platelets

Answer 11

cannot make new COX

no thromboxane production

Question 12

Aspirin effect on vascular endothelial cells

Answer 12

can make new COX

make prostacyclin at reduced rate