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Biochemistry > Lipid Digestion > Flashcards

Lipid Digestion Flashcards

1
Q

Acid Lipase

A

in stomach, ph 4-6

target TAG w/ short and medium FA

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2
Q

Lingual Lipase

A

Secreted from glands at back of tongue

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3
Q

Gastric Lipase

A

Secreted from gastric mucosa

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4
Q

Pancreatic Enzymes

A

digest dietary TAG, cholesteryl esters, phospholipids

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5
Q

Pancreatic Lipase

A

esterase
cleaves FA at C1 and C3 of glycerol backbone
makes 2 free FA and 2-monoacylglycerol

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6
Q

Colipase

A

from pancreas

binds pancreatic lipase and anchors it at lipid aqueous interface to promote PL activity in presence of bile salts

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7
Q

Cholesterol Esterase

A

from pancreas
digests esterified cholesterol
makes cholesterol and free FA
activity promoted by bile salts

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8
Q

Phospholipase A2

A

removes FA from position 2 to produce lysophospholipid and free FA

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9
Q

Lysophospholipase

A

removes FA from position 1 to make 1 FA and 1 glycerylphosphoryl base

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10
Q

Gut Endocrine Cells

A

in mucosa of lower duodenum and jejunum
sense lipids and partially digested proteins and low pH of chyme
secrete CCK and secretin

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11
Q

Cholecystokinin

CCK

A

peptide hormone secreted to blood in response to presence of lipids and partially digested proteins

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12
Q

CCK Function

A

promotes pancreatic enzyme secretion
makes gallbladder release bile
decreases gastric motility

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13
Q

Secretin

A

peptide hormone secreted to blood in response to low pH of chyme entering intestine

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14
Q

Secretin Function

A

promote release of bicarbonate rich solution from pancreas to SI
provides right pH for pancreatic enzyme activity

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15
Q

Lipid digestion in jejunum makes….

A

free FA
free cholesterol
2-monoacylglycerol

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16
Q

Micelles

A

disk shaped clusters of amphipathic lipids

formed from 3 products of bile salts and fat soluble vitamins (A,D,E,K)

17
Q

Fatty acyl CoA Synthetase

Thiokinase

A

converts LCFA to activated form by using E from ATP to make fatty acyl CoA

18
Q

TAG synthase

A

2-monoglycerol converted to TAG by enzyme that adds activated FA

19
Q

Acyl CoA: cholesterol acyltransferase

A

esterifies cholesterol with a FA

20
Q

Chylomicrons

A

TAG + cholesterol esters surrounded by monophospholipid layer, cholesterol, apolipoprotein B-48
made at ER of enterocytes
exocytosed into lacteals

21
Q

Chyle

A

lymph that has chylomicrons

22
Q

Lipoprotein lipase

A

degrades TAG in chylomicrons to free FA and glycerol

made and secreted by muscle and adipose

Biochemistry (14 decks)

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