ETC

Question 1

Outer Mitochondrial Membrane Permeability

Answer 1

ions and small molecules

use channels and porins

Question 2

Inner Mitochondrial Membrane Permeability

Answer 2

most small ions and small and large molecules

Question 3

Complex 1

NADH Dehydrogenase

Answer 3

iron sulfur center
accepts e- from NADH made during glycolysis, pyruvate decarboxylation, Krebs
makes FMNH2

Question 4

Complex 2

Succinate dehydrogenase

Answer 4

Embedded in inner membrane
iron sulfur center
makes FADH2

Question 5

Coenzyme Q

Answer 5

nonprotein

gets e- from C 1 and 2

Question 6

Complex 3

Answer 6

Cyt b and c1

Question 7

Complex 4

Answer 7

Cyt a + a3 or c oxidase
contains copper
gives e- to O2 acceptor

Question 8

Complex 5

ATP Synthase

Answer 8

Fo= spans inner memmbrane
F1= extramembranous
ADP + Pi = ATP

Question 9

Inhibitors of Complex 1

Answer 9

Amytal (barbituate)

Rotenone (insecticide)

Question 10

Inhibitors of Complex 3

Answer 10

Antimycin A (piscicide)

Question 11

Inhibitors of Complex 4

Answer 11

Cyanide
CO
Sodium azide (NaN3)

Question 12

Inhibitors of Complex 5

Answer 12

Oligomycin

Question 13

Uncoupling

Answer 13

Allows H+ to flow back through membrane without generating ATP

Question 14

Natural Uncoupling

Answer 14

Uncoupling proteins in inner membrane

Question 15

Synthetic uncouplers

Answer 15

Nonproteins that increase permeability of inner membrane to H+