PROLYMPHOCYTIC LEUKEMIA Flashcards
Coined before as a
“rare form of CLL”
Coined before as a
“rare form of CLL”
Prognosis =
PROLYMPHOCYTIC LEUKEMIA
The proliferation and accumulation of abnormal lymphoid cells in the spleen, BM and to a lesser extent, the liver account for the S/Sx of PLL
Predilection in men of the 6th decade
Generally acute in onset (as compared with the classic CLL)
Associated with hepatosplenomegaly
Lymphadenopathy is uncommon
PROLYMPHOCYTE CHARACTERISTICS:
Large
Mononuclear
Oval to round nucleus
Coarse appearing chromatin strands
One or two large vesicular nuclei
Perinuclear chromatin condensation
Basophilic agranular cytoplasm
LABORATORY FINDINGS
Leukocytosis
Absolute neutrophils low (1) to high (20)
+/- Absolute monocytosis
Marrow prolymphocytic infiltration
Anemia
Thrombocytopenia
TREATMENT GOALS
Reduce lymphocyte mass in the blood, marrow, and tissues
Improve hematopoiesis in patients who are bleeding and anemic
Prognosis =
PROLYMPHOCYTIC LEUKEMIA
The proliferation and accumulation of abnormal lymphoid cells in the spleen, BM and to a lesser extent, the liver account for the S/Sx of PLL
Predilection in men of the 6th decade
Generally acute in onset (as compared with the classic CLL)
Associated with hepatosplenomegaly
Lymphadenopathy is uncommon
PROLYMPHOCYTE CHARACTERISTICS:
Large
Mononuclear
Oval to round nucleus
Coarse appearing chromatin strands
One or two large vesicular nuclei
Perinuclear chromatin condensation
Basophilic agranular cytoplasm
LABORATORY FINDINGS
Leukocytosis
Absolute neutrophils low (1) to high (20)
+/- Absolute monocytosis
Marrow prolymphocytic infiltration
Anemia
Thrombocytopenia
TREATMENT GOALS
Reduce lymphocyte mass in the blood, marrow, and tissues
Improve hematopoiesis in patients who are bleeding and anemic
