CMPD - Chronic Myelogenous Leukemia

Question 1

Malignant disorder characterized by leukocytosis with increased mature and immature granulocytes

Answer 1

CHRONIC MYELOGENOUS LEUKEMIA

Question 2

CHRONIC MYELOGENOUS LEUKEMIA

Malignant disorder characterized by

is common

_ that is found in granulocytes, RBC, platelets and B cells

Answer 2

leukocytosis with increased mature and immature granulocytes

Thrombocytosis

Splenomegaly

(+) Philadelphia chromosome (Ph1)

Question 3

reserved for PH1- cases of infants and children

Answer 3

JUVENILE CML

Question 4

CHRONIC MYELOGENOUS LEUKEMIA

CLINICAL PRESENTATION

Answer 4

(+) lymphadenopathy

Fullness (hepatosplenomegaly)

Priapism

Question 5

CML

LABORATORY FINDINGS PERIPHERAL BLOOD

Answer 5

Marked WBC elevation (50-600 X 109/L)

Anemia if present is N/N

Platelets are inversely proportional to WBC count

Question 6

Dysplastic granulocytes and platelets ARE NOT CHARACTERISTIC of CML except in:

Answer 6

• Myeloid blast formation
• Ph1- CML
• Initial patients seen with CML in blast transformation

Question 7

CML

LABORATORY FINDINGS
BONE MARROW

Answer 7

Markedly cellular with minimal fat with predominance of the granulocytic series

Shift to the left

Increase megakaryocytes
(+) fibrosis

Question 8

found in cells of the malignant proliferating clone in 70% to 90% of patients with CML

Answer 8

PHILADELPHIA CHROMOSOME

Question 9

Results from the t(9q+;22q-)

Answer 9

PHILADELPHIA CHROMOSOME

Question 10

Must be differentiated with

Answer 10

“Leukemoid reaction”