AGNOGENIC MYELOID METAPLASIA Flashcards
1
Q
Aka
A
Aka IDIOPATHIC MYELOID METAPLASIA
MYELOFIBROSIS WITH MYELOID METAPLASIA
IDIOPATHIC MYELOFIBROSIS
2
Q
AMM Describes a clonal chronic myeloproliferative disorder characterized by :
A
Fibrosis – a secondary reaction
Granulocyte hyperplasia in the marrow
Proliferation of granulocytes in the spleen and the liver
3
Q
AMM Consistent findings
A
defective platelets secondary to dysplastic megakaryocytopoiesis
4
Q
Alpha granular release –> PDGF –> Fibrosis
A
Alpha granular release –> PDGF –> Fibrosis
5
Q
CLINICAL PRESENTATION
A
Anemia Abdominal pain Indigestion and fullness Fever and night sweats Patients appear ashen Liver enlargement Epistaxis Petechiae
6
Q
AMM
LABORATORY FINDINGS
PERIPHERAL BLOOD
A
DACROCYTOSIS
Occasional nRBC
7
Q
AMM
LABORATORY FINDINGS
BONE MARROW
A
Dry tap Reticular fibrosis or collagen deposition Hypocellularity Increased megakaryocyte Osteosclerosis (end stage)
