ET

Question 1

Second rarest after CNL

Answer 1

ESSENTIAL THROMBOCYTHEMIA

Question 2

Closely related to PV but with no accompanying erythrocytosis

Answer 2

ESSENTIAL THROMBOCYTHEMIA

Question 3

ET

A chronic MPD characterized by __ in excess of __ with spontaneous aggregation of functionally abnormal platelets

Answer 3

thrombocytosis

1000 X 109/L with spontaneous aggregation of functionally abnormal platelets

Question 4

CLINICAL PRESENTATION

Answer 4

Frequent episodes of epistaxis
Hematemesis
GI bleeding
Gangrenous toes

Question 5

LABORATORY FINDINGS

PERIPHERAL BLOOD

Answer 5

Marked thrombocytosis

Platelet aggregates with giant and bizarre forms

Platelet anisocytosis

Occasional megakaryocyte fragments

RBC count is slightly elevated

Micro/hypo anemia

Howell Jolly bodies

Leukocytic shift to the left

Question 6

ET

LABORATORY FINDINGS

BONE MARROW

Answer 6

“dry tap”

Hypercellular with megakaryocytic hyperplasia

Aggregated platelets

“glued together” appearance

Erythroid and granulocytic hyperplasia