HEMATOPOIETIC MALIGNANCIES

Question 1

condition where abnormal cells are present in the marrow and the peripheral blood

Answer 1

LEUKEMIA

Question 2

Abnormal cells that are confined to the bone marrow and DO NOT circulate

Answer 2

ALEUKEMIC LEUKEMIA

Question 3

neoplastic growth that are confined to lymphatic tissues (such as lymph nodes) resulting in solid lymphatic tumors

Answer 3

LYMPHOMA

Question 4

lymphoma that has spread to the bone marrow and peripheral blood

Answer 4

LEUKEMIC LYMPHOMA

Question 5

MORPHOLOGIC EVIDENCE OF MALIGNANCY

NUCLEAR

Answer 5

Shape abnormalities
Multinuclearity
Megaloblastoid (unresponsive to vitamin B12 or folate)
Hyposegmentation (pseudo Pelger-Huet) or hypersegmentation
Giant of prominent nucleoli
Increased mitotic figures

Question 6

MORPHOLOGIC EVIDENCE OF MALIGNANCY

CYTOPLASMIC

Answer 6

Abnormal granules (Auer rods)
Mixed granulation (basophil or eosinophil)
Decreased granulation
Increased fragility (cytoplasmic fragmentation)

Question 7

MORPHOLOGIC EVIDENCE OF MALIGNANCY

OVERALL

Answer 7

Abnormal size (gigantism or dwarfism)
Tendency to cluster or clump
Clonal morphology (all abnormal cells appear similar)

Question 8

MYELOID – involves

Answer 8

• granulocytes,
• monocytes,
• erythrocytes, or
• megakaryocytes

Question 9

MYELOID - Also called

Answer 9

MYELOPROLIFERATIVE DISORDERS or NON-LYMPHOCYTIC LEUKEMIAS

Question 10

LYMPHOID involves

Answer 10

involves the B- and the T-cells and may either be leukemias or lymphomas

Question 11

ACUTE %

CHRONIC %

Answer 11

ACUTE
>30% blast forms in the peripheral blood or 50% in the bone marrow

CHRONIC

Question 12

Gray zone of 10-30% blasts

Classified as

Answer 12

SUBACUTE,
CHRONIC, or
CHRONIC TRANSFORMING TO ACUTE

Question 13

Acute leukemias

Answer 13

1) ACUTE MYELOID/NON-LYMPHOCYTIC LEUKEMIA (AML or ANLL)
- –(M1-M7)
2) ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- –L1-L3

Question 14

Chronic leukemias

Answer 14

GRANULOCYTIC (MYELOCYTIC) LEUKEMIA (CML/CGL)
POLYCYTHEMIA VERA (PV)
AGNOGENIC MYELOID METAPLASIA WITH MYELOFIBROSIS (AMM)
PRIMARY (ESSENTIAL) THROMBOCYTHEMIA (ET)

Question 15

Chronic lymphoproliferative leukemias

Answer 15

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
PROLYMPHOCYTIC LEUKEMIA (PLL)
HAIRY CELL LEUKEMIA (HCL)

Question 16

The solid tumors of lymphatic tissue (LYMPHOMA) addresses a unique lymphoid malignancies that cannot be classified as leukemia or lymphoma in the strictest sense :

Answer 16

PLASMA CELL DYSCRASIAS

Question 17

PRELEUKEMIA

Answer 17

(MYELODYSPLASTIC or DYSMYELOPOIETIC SYNDROMES)