Prolactin Flashcards
prolactin
protein hormone from anterior pituitary that induces lactation; single chain, 4 alpha-helixes, together w/disulfide bridges
lactation
produced by prolactin
alveolus (mammary gland)
formed by secretory cells at base of duct network
mammary gland secretory cell
grouped into lobules, form alveolus, make milk products
myoepithelial cell
squeeze alveolus, push on individual secretory cells, pushes milk to ducts
dopamine neuron (hypophysiotropic factor)
releases inhibitory CS
Gi protein
intact when DA is not released and gated K+ channel is closed
follicular phase
normal production of estrogen
luteal phase
normal production of progesterone
estrogen
normal production when prolactin is normal
progesterone
normal production when prolactin is normal; high when pregnant
amenorrhea
prolactin high, estrogen low, progesterone low
bromocriptine
synthetic DA; use when high prolactin secretion
haloperidol
treatment when prolactin low; DA antagonist
testosterone
normal production when prolactin is normal; if low = sperm quality affected