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Endocrinology Exam 1 > Growth Hormone > Flashcards

Growth Hormone Flashcards

1
Q

growth hormone

A

influences physiology of bone, muscle, and adipose cells while working w/insulin-like GF1; 191 AA = big

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2
Q

IGF1

A

insulin like growth factor; released when GH binds to liver cells and by chondrocytes

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3
Q

cartilage

A

flexible, but strong

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4
Q

bone matrix

A

support structure; no cartilage cells; matrix of calcium carbonate crystals

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5
Q

epiphyseal plate

A

composed of chondrocytes; young divide at top, oldest die at bottom; cells divide = bone gets longer

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6
Q

chondrocytes

A

in plate; young divide and are target for GH, old lay down matrix, oldest die

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7
Q

osteoblast

A

bone cells that degrade cartilage and bone

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8
Q

osteoclast

A

bone forming cells; lay down new matrix

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9
Q

inhibitory neurons

A

ss neuron in hypothalamus attached to inhibitory neuron; when on = ss silenced; when inhibited = ss released

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10
Q

passive Na+ channel

A

moves out to in

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11
Q

passive K+ channel

A

moves in to out

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12
Q

gated Ca++ channel

A

moves out to in

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13
Q

depolarization

A

(-) to (+) membrane potential

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14
Q

ghrelin

A

can activate somatotropes; released when stomach shrinks; induces release of GH = release of glucose

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15
Q

dwarfism

A

under produce; in adolescents; premature close plate; GH low, IGF1 low = GHRH/receptor; GH high, IGF1 low = GH receptor/synthesis

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16
Q

laron dwarfism

A

chondrocyte issue; GH receptors; GH normal, IGF1 normal

17
Q

achondroplasia

A

mutations in fibroblast GFR 3 gene; not GH or IGF1

18
Q

gigantism

A

over produce; hyper GH; somatotrope adenoma; making GH out of control, GH high and IGF1 high

19
Q

acromegaly

A

unproportionable; somatotrope tumor in adult; divide out of control; bones can’t get longer but can get denser

20
Q

types of Ca++ channels in somatotropes

A

ligand gated and voltage gated

Endocrinology Exam 1 (8 decks)

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