Biosynthesis 2

Question 1

polypeptide hormone

Answer 1

made in epithelial/neurosecretory cells

Question 2

transcription

Answer 2

DNA to RNA

Question 3

post-transcriptional processing

Answer 3

splicing, 5 capping, poly A tail

Question 4

co-translational processing

Answer 4

signal sequence of nascent polypeptide removed by signal peptidase

Question 5

signal recognition protein

Answer 5

(SRP) recognizes and binds SS; stops translation; can release SS and resume

Question 6

translocon

Answer 6

docking protein; make contact w/SRP receptor

Question 7

signal peptidase

Answer 7

cuts off SS; cleave signal peptides from n-termini; convert secretory proteins to mature

Question 8

prohormone convertase

Answer 8

remove chain of AA to activate protein/hormone; looks for 2 AA side by side

Question 9

Ca++ binding protein (on RSV)

Answer 9

where Ca++ enters cytosol and binds

Question 10

exocytosis

Answer 10

contents of cell released to exterior through fusion of vacuole membrane w/cell membrane

Question 11

catecholamine precursor

Answer 11

tyrosine

Question 12

catecholamine rate limiting step

Answer 12

tyrosine hydroxylase

Question 13

catecholamine can the CS be stored in RSV

Answer 13

yes

Question 14

catecholamine can epithelial cells make CS

Answer 14

yes

Question 15

catecholamine can neurosecretory cells make CS

Answer 15

yes

Question 16

polypeptides precursor

Answer 16

protein that begins w/SS

Question 17

polypeptides rate limiting step

Answer 17

expression of hormone coding gene

Question 18

polypeptides can CS be stored in RSV

Answer 18

yes

Question 19

polypeptides can epithelial cells make CS

Answer 19

yes