Biosynthesis 3

Question 1

cholesterol

Answer 1

make in liver and through duct

Question 2

hormone receptor (on SH producing cell)

Answer 2

binding causes shape change in receptor and activates G protein

Question 3

adenylyl cyclase (AC)

Answer 3

synthesizes cAMP from ATP; ATP to cAMP

Question 4

protein kinase A (PKA)

Answer 4

phosphorylates substrate proteins; activates phosphorylase kinase

Question 5

steroidogenic acute regulatory protein (StAR)

Answer 5

opens once phosphorylated; moves cholesterol along lumen and in

Question 6

cholesterol ester hydrolase (CEH)

Answer 6

rate limiting factor in SH pathways; once phosphorylated cholesterol is released

Question 7

enzyme chain

Answer 7

product from one reaction becomes substrate for next reaction

Question 8

rate limiting steps in biosynthetic pathway

Answer 8

regulation of StAR; regulationg of CEH

Question 9

steroid hormone precursor

Answer 9

cholesterol

Question 10

steroid hormone rate limiting step

Answer 10

CEH and/or StAR

Question 11

steroid hormone can CS be stored in RSV

Answer 11

no

Question 12

steroid hormone can epithelial cells make steroids

Answer 12

yes