Problems of Oxygenation - Part 2 Flashcards
What are the different types of LC?
Non-small cell LC
- squamous, adenocarcinoma, large cell LC
Small cell LC
- small cell LC
How is LC diagnosed?
Usually through imaging - CT, MRI or PET scan
Can also do a lung scan, pulmonary angiography (dye), fine needle aspiration and bronchoscopy/mediastinoscopy
What are the different treatments for LC?
Thoracotomy Lobectomy, pneumonectomy radiation Chemo Biological therapy phototherapy Cryotherapy
Describe the indication or contraindication for the following LC treatments.
Surgery
Radiation
Chemo
Surgery - not for small cell as there is widespread metastasis
Radiation - used in combination with surgery and chemo for palliation
Chemo - improved survival in NSCLC
Tissue is destroyed by freezing via bronchoscope
Cryotherapy
Describe how phototherapy works.
IV injection of Phtofrin, concentrates in tumour cells. 48 hours later, laser light applied and a toxic oxygen form destroys tumour cells.
Necrotic tissue is then removed by bronchoscope.
What are some examples of biologica therapies?
IFNs, ILs (interleukins), Monoclonal Abs, Hematopoeitic GFs (growth factors)
Interferes with cancer cell’s ability to metastatize or differentiate, or restore hosts immune mechanism
Biological therapy
Where does a bronchoscope go?
Through nose, into bronchus
Blockage of an artery in the lungs by a substance that has traveled from elsewhere in the body via the bloodstream.
Pulmonary embolism
Symptoms of PE?
SOB, chest pain (esp. when breathing in) and hemoptysis
symptoms of a leg clot may also be present - red, warm, swollen and painful leg
What are signs of PE?
Low SpO2, tachypnea, tachycardia, mild fever
Severe cases - very low BP, sudden death, loss of consciousness
PE usually results from what?
A blood clot in the leg that travels to the lung
phenomenon that is experienced by the individual affected by the disease; subjective
symptom
phenomenon that can be detected by someone other than the individual affected by the disease; objective
sign
When a person has a PE, where are they sent?
ICU - high risk of coding (respiratory arrest)
What is Virchow’s triad?
Signs that predispose a person to blood clots. these are:
- Venous stasis
- Hypercoaguability
- Venous endothelial disease
What are certain disease states that predispose a person to PE?
post-op/postpartum, heart disease, diabetes, COPD
If smoking and over ___, doctors will not give what to patients? Why?
35, oral contraceptives
Because there is a higher risk for developing blood clots
What used to be a very serious risk factor that contributed to DVT in the older days?
Pantyhose
How is PE diagnosed?
How is it treated?
Dx = based on S&S in combination with test results
Tx - heparin(ize), thrombolytics, CXR, VQ scan, D-dimer test
A lung ventilation/perfusion scan, measures air and blood flow in lungs. most often used to help diagnose/rule out a pulmonary embolism.
VQ scan
Blood test to rule out presence of a thrombus. Measures a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by firbinolysis. Released after a blood clot breaks up.
D-dimer test
What are conditions in which the D-dimer test is used to help rule out the presence of a thrombus?
Stroke, DVT, PE