Diabetes Flashcards
What are the most common signs of diabetes?
Urinary frequency and excessive thirst
What does diabetes stand for?
What does mellitus stand for?
Diabetes - siphon
Mellitus - sweet
Diabetes - Stats
- the majority (80%) of people with diabetes will die as a result of ______ _____ or _______
How does peripheral vascular disease occur as a result of diabetes?
heart disease, stroke
small arterioles in the lower leg calcify leaving to PVD and often amputations
What is type I diabetes?
What proportion of diabetics are type I?
When are most cases diagnosed?
What used to be another name for type I diabetes?
Occurs when the pancreas does not produce insulin (autoimmune disorder where the Beta cells of the islets of Langerhans are attacked)
Accounts for 10% of all diabetics
Most cases Dx before age 30
Juvenile diabetes - name no longer used
Who discovered insulin?
Where was early insulin extracted from?
What do we use now?
Dr. Frederick Banting
Pigs and cattle
Now use synthetic (many ppl are allergic to porcine/bovine insulin)
Describe Type II diabetes.
What proportion of diabetics are type II?
How are the majority (75%) of cases diagnosed?
Type II diabetes is either due to the pancreas not producing enough insulin, or the body does not effectively use the insulin that is produced
90%
Incidentally through routine/incidental testing
Type II diabetes is developing in children at an alarming rate, why?
Obesity epidemic
- especially in latin immigrants, but also home grown children
What is needed to prevent children from developing type II diabetes?
Lifestyle changes - exercise and weight reduction
How is sugar consumption related to obesity (at least according to her slides).
Sugar consumption can lead to a fatty liver and consequently to metabolic disorders
Type II - Who is at risk?
- Over ___ years old
- High risk ethnic groups - basically everyone but?
- number one risk factor
- Family Hx
- Birth related?
- high ______ or high _______ ______
40 everyone but Europeans and Caucasians Obesity - number one risk factor Hx of gestational diabetes or giving birth to a high birth weight baby High cholesterol or BP
What is a special population to consider when thinking about type II diabetes risk in Canada?
Canadian Aboriginal people
Type II and Aboriginal people:
- - x more likely than the general population to have type 2
- Estimated that ___% of individuals in First Nations communities over 45 have DM
3-5x
25%
Diabetes that is a temporary condition that occurs during pregnancy.
Gestational diabetes
Gestational diabetes:
- Placenta produces _____ and ______ - this allows more sugar to the get to the baby, causing a larger birth weight baby
- When this occurs, women are not as healthy during pregnancy, often need bedrest later on
- after the baby is delivered, the mother and child should be fine, but carry around a high risk of developing this disease
cortisol, estrogen
high risk of developing type II diabetes
How are women screened for gestational diabetes?
Glucose tolerance test
Glucose intolerance
Secretion of placental hormones
What are the most important modifiable risk factors for the development of type II diabetes:?
Diet, exercise and weight
- managing these can lead to reversal of type 2
What are the three most important non-modifiable risk factors for type II diabetes?
age, genetics, ethnicity
number associated with a particular type of food that indicates the food’s effect on a person’s blood glucose level.
Indicates how quickly food glucose is absorbed.
Glycemic index - GI
Frequent or recurring infections, cuts or bruises that are slow to heal, tingling or numbness in the hands or feet, and trouble getting or maintaining an erection are all _____ signs of uncontrolled blood sugar.
later
excessive thirst due to hypovolemia
polydypsia
If glucose is not being taken up by the cells, what will start accumulating in their blood and urine?
Ketone bodies
Why does diabetes often precipitate infections or cause recurring infections?
Hypoglycemia –> increase glucose in the fluid of the tissues (But not in the cells) = favourable medium for bacteria
What is the physiological mechanism for polydypsia?
Glucosuria pulls water from the body, increasing thirst