Principles of Chemotherapy Flashcards
Define cytocidal.
Causes cell death, irreversible, can lead to release of dangerous endotoxins
Define cytostatic.
Prevention of cell multiplication without cell death, reversible
Name the four target categories.
Bacteria, viruses, fungi and protozoa.
Name three ways we classify antimicrobial drugs.
Mode of action, site of action in target organism and types of target organism.
Name to microbial factors
Natural distribution of microorganisms and microbial pathogenicity
Name some factors that affect the host.
Immunocompromised patients, allergies, drug interations, kidney or liver dysfunction, circulation, prgenancy and lactation and age
What are disadvantages of anti microbial drugs?
Resistance, super infection and side-,allergic, toxic effects, masking of infection and treatment failure.
Name different bacteria shapes.
Coccus, Bacillus and Spiral
What does bacterial cell growth tell us?
Monitors whether or not a a drug is bactericidal or bacteriostatic
What is the Gram stain technique?
Test that is based on the ability of the bacterial cell wall to retain the primary dye, crystal violet.
List the characteristics of a cram positive bacteria cell
stains purple, thicker cell wall, smooth cell wall, 50% peptidoglycan
List the characteristics of a gram negative bacteria cell
Stains pink, periplasmic space outsdie plasma membrane, convoluted cell surface
What is a class I reaction?
Glycolysis, citric acid cycle
What is a class II reaction?
Synthesis of nucleotides, amino acids and hexosamines
What is a Class III reaction?
Synthesis of macromolecules, proteins, peptidoglycan, nucleic acids
