Hormones and Monoclonal Antibodies Flashcards
What does cortisol regulate?
Carbohydrate metabolism and anti-inflammatory effects
What is oestrogen used for?
Palliative treatment of androgen dependent prostatic tumours
What is oestrogen’s mechanism of action?
Negative feedback inhibition of GnRH secretion from HT
How is oestrogen administered?
Orally
What are the side effects of oestrogen?
GI upset
breast swelling
fluid retention
What is progesterone used for?
Treatment of endometrial cancer
How is progesterone administered?
Pill or liquid
What are the side effects of progesterone?
Hot flashes
Night sweats
depression
What effect does oestrogen have on breast tissue and endometrial lining?
Proliferative effects
Promote tumour growth
What do oestrogen receptors (ER) change?
Gene transcription
What does alpha ER activation cause?
Enhanced proliferation
What does beta ER activation cause?
Antiproliferative effect
What is the role of tamoxifen and toremifene?
Selectively stimulate and inhibit oestrogens in different tissues
Partial agonists and antagonists at ER depending on dominant receptor
What is the MoA of Tamoxifen?
Blocks action of oestrogen - inhibits growth of Bca
Upregulates TGF beta
What does Tamoxifen act on?
Liver to lower circulating cholesterol
