Principles of Autoimmunity

Question 1

What are cryptic antigens?

Answer 1

Intracellular antigens released during cell injury or death

Question 2

True/False. In a healthy person, there are no antibodies that react to self antigens.

Answer 2

False. All individuals have a certain level of natural antibodies and autoreactive lymphocytes. These assist with clearance of apoptotic bodies, immune surveillance, protection of tissues, and maturation of dendritic cells

Question 3

True/False. Females are more at risk for autoimmune disorders.

Answer 3

True. The female immune system is more complex than male due to pregnancy

Question 4

Immune respones directed at a single organ or tissue are generally what type of hypersensitivity?

Answer 4

Type 2 Hypersensitivity

Question 5

Type 3 Hypersensitivities are generally direct at (single organ/systemic)?

Answer 5

Systemic or generalized

Question 6

What HLA allele is most associated with ankylosing spondylitis?

Answer 6

B27

Question 7

DRB1 is associated with what disease?

Answer 7

Type 1 Diabetes

Question 8

What cytokine is associated with proliferation of Th17 cells?

Answer 8

IL-23

Question 9

What T cell receptor binds B7 and serves as an inhibitory pathway to CD28 stimulation?

Answer 9

CTLA-4