Pharmacology of Antivirals Flashcards
What NRTI is associated with hypersensitivity reaction in a small percentage of patients?
Abacavir
What integrase inhibitors are used in HIV treatment?
Raltegravir, elvitegravir, dolutegravir, bictegravir
What ADR is associated with cidofovir?
Nephrotoxicity
Ribavirin & IFNa are used in the treatment of…?
Hepatitis C
What neuraminidase inhibitors may be used to treat influenza?
Zanamivir & Oseltamivir
What ADRs are associated with acyclovir?
Nephrotoxicity
What NRTIs are commonly used in HIV treatment?
Tenofovir & Emtricitabine
What protease inhibitor is used in HIV treatment and has many drug-drug interactions due to its metabolism by Cyp450 enzymes?
Ritonavir
What drug is used daily to treat recurrent HSV flares?
Valacyclovir
What ADRs are associated with Efavirenz?
CNS disturbances - dizziness, nightmares, delusions
Bone marrow suppression and myelosuppression are ADRs associated with which antiviral?
Ganciclovir
A patient fails HSV treatment with acyclovir and cidofovir. What is the next antiviral drug of choice?
Foscarnet
True/False. Acyclovir must be phosphorylated by a viral kinase for activation.
True - phosphorylation by a viral kinase and then two cell kinases
What is the MOA of acyclovir & valacyclovir?
Guanisine nucleoside analog that inhibits DNA synthesis when inserted
What antiviral is effective in treating varicella and shingles?
Valacyclovir
What antiviral can be used to treat resistant HSV, CMV, and ZVZ?
Cidofovir & forcarnet
What NNRTIs may be used in HIV treatment?
Efavirenz, Nevirapine, Delaviridine
