Drug Distribution

Question 1

What factors influence drug distribution in the body?

Answer 1

Plasma proteins, L/W coefficient, membrane permeability, BBB, placental barrier

Question 2

True/False. The concentration of drug in whole blood and plasma is the same.

Answer 2

False. The concentration of a drug is always less in the whole blood then the plasma alone. The amount of drug is the same, however.

Question 3

What effect will decreased drug concentration have on binding?

Answer 3

Increases binding

Question 4

What effect does a lower dissociation value have on binding?

Answer 4

Increased binding

Question 5

Only (free/bound) drug can be filtered by the kidney and transfer across membranes.

Answer 5

Free drug

Question 6

What effect does protein binding have on half-life?

Answer 6

Protein binding increases half-life to provide a reservoir of drug

Question 7

What blood protein is most involved with drug binding?

Answer 7

Albumin