Priming 1-4

Question 1

Advantages/disadvantages: atenolol vs. propanolol

BB

Answer 1

atenolol - selective spares lungs

propanolol - non-selective, blocks heart/lungs, don’t use own asthma/COPD patients

Question 2

Advantages/disadvantages: verapamil, cardiziem, amlodipine

CCB

Answer 2

verapamil - cardioselective and decreases HR and contractility
cardiziem - acts on cardiac and peripheral smooth muscle
amlopdipine - acts on peripheral smooth muscle in arteries to VD

Question 3

Advantages/disadvantages: hydrochlorothiazide, spironolactone

diuretics

Answer 3

hydrochlorothiazide - oldest drug, very effective, cheap, but also loses potassium, can cause dysrhythmias, req K supplements

spironolactone - enhances water excretion, but spares K+, not as effective in lowering BP

Question 4

Advantages/disadvantages: lisinopril, valsartan

ACE inh/ARB

Answer 4

lisinopril (ACE) - lowers BP, blocks conversion

valsartan (ARB) - blocks receptor site, coughs

Both reduce peripheral resistance

Question 5

Therapeutic effect of Dig?

Answer 5

Increase myocardial contractility
Increase CO at rest and exercise
Improve exercise tolerance
Decrease HF symptoms, hospitalizations

Question 6

MOA: Dig

Answer 6

Increases intracellular Ca concentration, inhaling contractility, myosin/actin interaction
Inhibits Na-K pump
More Ca released during AP so stronger contraction
Slow HR and electrical conduction through myocardium
Stim vagus