Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PT 539 Pharmacology > NSAIDS, Tylenol > Flashcards

NSAIDS, Tylenol Flashcards

1
Q

COX-1 & COX-2 (drugs)

A

Aspirin (small dose good for cardio)
Ibuprofen (Motrin, Advil)
Naproxen

GI upset/bleed
Abdominal pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

COX-2 (drugs)

A

Celebrex/Celecoxib

Reduces pain, fever, inflammation

GI protected!!
No anti-platelet effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Acetaminophen

A

Tylenol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Acetaminophen

A

analgesic
anti-pyretic

NOT anti-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

NSAIDS

A 
anti-inflammatory
anti-pyretic
analgesic
anticoagulant
anticancer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Acetaminophen: MOA

A

Blocks COX enzyme in brain/spinal cord

*pain & fever!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

NSAIDS (selective): MOA

Aspirin

A

inhibits COX, ALL PGs

reduces pain, stiffness, swelling
fever reduction due to vasodilation of superficial blood vessels
inhibits platelet aggregation
Prevents MI and reduces coronary artery thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NSAIDS (non-selective): MOA

A

-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PGs

A

responsible for inflammation, pain, fever, coagulation
hormones created during chemical run at site of injury
not secreted, but are created at the time problem exists

*amount of dosage will dictate which PGs it will inhibit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

COX-1

A
  • help regulates normal cell activity and maintain homeostasis
  • synthesizes PGs to protect cells, maintain function
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

COX-2

A
  • induced when cell is injured
  • synthesizes PGs that mediate pain, inflammation
  • used in patients with RA, OA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which drug is the oldest non-narcotic and is derived from willow bar?

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which drug is associated with Eye syndrome in meds?

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which drug is NOT effective for chronic pain?

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is interactive with aspirin?

A

higher dosage of NSAID blocks the cardioprotective effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do baby aspirin help prevent?

A

clots, DVT, MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are side effects of aspirin?

A

GI distress/bleeding/ulcer
Renal dysfunction
Rene syndrome in peds

18
Q

What is Reye Syndrome?

A

Sudden (acute) brain damage and liver function problems of unknown cause. Up to 14 years if given for viral infection.

19
Q

At high dosage of aspirin what are some effects?

A 
tinnitus
vertigo
hyperventilation
respiratory alkalosis
metabolic acidosis
dehydration
hyperthermia
coma & death
20
Q

How long is aspirin permanently binded on RBC?

A

7-12 days

21
Q

Where is aspirin absorbed?

A

stomach and intestine

22
Q

Can it cross into placenta and breast milk?

A

Yes

23
Q

What is the half life of aspirin?

A

2 hours

Administer every 4 hours

24
Q

What are contraindications of aspirin?

A 
peptic ulcers
DM
gastritis
hemophilia
warfarin
alcohol
hyperkalemia
increase risk of cerebral hemorrhage
25
Q

What are interactions with aspirin?

A 
DM meds
Warfarin
Methotrexate
Spironolactone
Penicillin
Inhibit absorption of Vit C
26
Q

You can get instant relief with one dose of what drug?

A

Ibuprofen

27
Q

How many days does it take for ibuprofen to have an anti-inflammatory effect?

A

3 days to weeks

28
Q

What has a lower risk of GI bleeds?

A

Ibuprofen (Motrin, Advil)

29
Q

What are advise effects of NSAIDS?

A

> 65 co-morbidities

heart failure, GI ulceration, renal impairment

30
Q

What are contraindications of ibuprofen?

A

hypersensitivity with other NSAIDS
Active GI bleed
peptic ulcer
4rd trimester

31
Q

What COX-2 drug can be taken with anticoagulants?

A

Celebrex

32
Q

What is the primary concern for celebrex/?

A

Increase risk of MI & Stroke!

COX-2 inhibition may cause selective loss of PGs that cause vasodilation an prevent thrombosis

33
Q

What are pathologies that celebrex is used for?

A

OA
RA
Enclosing spondylitis
Dysmenorrhea

34
Q

What are common side effects of celebrex?

A

GI
back pain
headache
High blood pressure

35
Q

What are uncommon side effects of celebrex?

A 
heart failure
confusion
asthma
kidney impairment
blurred vision
tinnitus
GI ulceration
36
Q

Which drug is the choice for children?

A

Acetaminophen

37
Q

What are the side effects of acetaminophen?

A

inhibits RBC/WBC/neutrophils to produce by bone marrow and becomes immunocompromised with certain dosage

38
Q

Which drug has a unique anti-platelet effects at low dose?

A

Aspirin

39
Q

Which drug is used for chronic pain?

A

Celebrex

40
Q

Which drug is high risk for GI bleed?

A

Aspirin

41
Q

Which drug acts quickly for pain an dress risk for GI?

A

Ibuprofen

PT 539 Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions