Lecture 2 Flashcards
Hypertension
Develops when blood volume > the space available inside blood vessels
CO = SV x HR
SV - influenced by contractility
EDV - preload
MAP?
BP x TPR
What the the difference between ACE inhibitor and ARB?
ACE inhibitors prevents conversion of angio1 to angio 2
ARB blocks the receptors
How does diuretics effect cardiovascular drugs?
They eliminate volume. Decrease pressure. Decreasing HR. Decreasing TPR.
MOA: Diuretics
Lowers plasma volume, increase urine production.
MOA: Ca channel blockers (selective), beta-blockers
Decrease cardiac contractility (SV)
MOA: ACE inhibitor, ARB, Ca channel blockers (selective)
Dilates peripheral arteries
Diuretics (Hydrochlorothiazide) acts on what components?
Nephrons
Loop of Henle
How will diuretics (Hydrochlorothiazide) help physiologically for hypertension?
Increase sodium and water elimination
Increase urine output, decreasing vascular fluid volume
What are some concerns with diuretics (Hydrochlorothiazide)?
Dehydration, dizziness, light-headedness, potassium depleting, electrolyte imbalance, hypokalemia
Where does Spironolactone Potassium act on?
Collecting ducts
What does Spironolactone Potassium allow?
Allows Na and water to be excreted but NOT K+
Not as effective as thiazides
Where does beta-blockers block?
b1 on SA and AV nodal tissue
- decreases rate of depolarization, calcium influx
b2 on bronchiolar smooth muscle
- decrease bronchodilation
What is a side effect of ACE inhibitors?
Cough
