Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PT 539 Pharmacology > Parkinson's > Flashcards

Parkinson's Flashcards

1
Q

PD?

A

Idiopathic progressive neurodegenerative disorder.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What type of neurons are depleted in PD?

A

Loss of dopaminergic neurons.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where does the pathology occur?

A

Substantia nigra

Basal ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are some classic motor symptoms of PD?

A

Tremor
Rigidity
Akinesia
Postural control

Difficulty initiating movements: cognitive and motor, decreased amplitude

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are some non motor symptoms?

A

Fatigue
Cognitive dysfunciton
Difficulty sleeping

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the 3 medications for PD?

A

1) Carbidopa/Levodopa 25/100 (Sinemet)
2) Carbidopa/Levodopa (50/200)
3) Azilect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What classification is Levodopa?

A

Enzyme inhibitor & Agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What classification is Carbidopa?

A

Enzyme inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What classification is Azilect?

A

Monoamine oxidase-B inhibitor

MAOB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MOA of Carbidopa/Levodopa?

A

Converted to dopamine by dopadecarboxylase to attach to dopamine receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of Azilect?

A

Reduces/slows the breakdown of dopamine, resulting in increased levels of dopamine in the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Clinical application of Carbidopa/Levodopa?

A

More dopamine available in the brain allows for better movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Clinical application of Azilect?

A

Less dopamine broken down in the brain allows for better movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Common adverse reactions?

A

GI upset
Orthostatic hypotension
Dyskinesia
Psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Potential interactions of Carbidopa/Levodopa?

A

w/ MAOB, severe elevation of BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Potential interactions of Azilect?

A

Antidepressants that increase serotonin levels

Amphetamines and VC increases HTN events

17
Q

How does Carbidopa/Levodopa work together?

A

Carbidopa acts as a transporter for L-dopa to cross BBB

18
Q

What are two other agonist drugs for PD?

A

Mirapex and Requip

19
Q

What are limitations to PD drugs?

A

Response to medication changes over time, meds may need to be increased due to less responsive

20
Q

What is our role as PT?

A

Know the signs if drugs are effective for our patients and time accordingly to have an effective treatment session

21
Q

As drug lose effectiveness what can be educated?

A

Off times increase may need to change the dose, change the drug, add a drug, timing of meds

22
Q

The longer the patient is on the drug timing is much more important. T/F? Why?

A

True. Difficult to raise blood levels back up to therapeutic levels

23
Q

What two drugs are neuroprotective, slows down degeneration?

A

Azilect & Mirapex

24
Q

What percentage of dopamine do you lose before there are S&S?

A

60-80%

PT 539 Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions