Lecture 4

Question 1

INR

Answer 1

Assesses Coumadin

Question 2

PPT

Answer 2

Assesses levels of heparin

Question 3

Vitamin K

Answer 3

inhibition of this will decrease synthesis of clotting factors

Question 4

Clot breakdown

Answer 4

Tissue plasminogen activator converts plasminogen to Plasmin (fibrinolysis) breakdown the fibrin mech/clot
BALANCE between formation and breakdown is key for homeostasis

Question 5

What are the 3 classification of drugs to treat clotting disorders?

Answer 5

Anticoagulants - body’s own thrombolytic (plasma) can bust the clot
Antiplatelet - inhibits lately aggregation
Thrombolytics - clot buster, dangerous

Question 6

What are the 4 categories of anticoagulants?

Answer 6

1) Direct thrombin inhibitors
2) Indirect thrombin inhibitors
3) Vitamin K epoxide reductase inhibitor
4) Direct Xa inhibitor

Question 7

What are the 3 categories of antiplatelets?

Answer 7

1) COX inhibitors
2) Glycoprotein lib/IIIa inhibitors
3) ADP inhibitors

Question 8

What is the one category for thrombolytics?

Answer 8

Plasminogen activators

Question 9

Due to the slow onset with Coumadin…

Answer 9

Heparin is administers through IV

Question 10

What is the acceptable ratio for INR?

Answer 10

0.8 - 1.2

Question 11

MOA: Statin

Answer 11

Increase hepatic uptake of LDLs

Atovastatin blocks liver cholesterol production

Question 12

CCB

Answer 12

Decreases SA node automaticity, slows AV node conduction velocity and decreases HR

Question 13

Dig

Answer 13

Increases contractility force of the heart
Increases CO at rest and during exercise
Decrease conduction through AV via vagus nerve

Question 14

Coumadin

Answer 14

Increase clotting time