Primary haemostasis failure

Question 1

presentation of primary haemostasis failure?

Answer 1

-Spontaneous bruising and purpura
Mucosal bleeding – epistaxis, GI, conjunctival, menorrhagia
-Intracranial haemorrhage
-Retinal haemorrhage

Question 2

differential diseases of primary haemostasis failure?

Answer 2

-Von Willebrand Disease
-Haemophilia A and B
-DIC
-Thrombocytopenia

Question 3

vascular causes of primary haemostasis failure?

Answer 3

causes: vascular, platelet and von willebrand factor

Vascular- loss of collagen:
-Age
-Marfans
-HSP vasculitis
-Vit C deficiency (scurvy)

Question 4

platelet causes of primary haemostasis failure?

Answer 4

can be split into decrease in number and decrease in function

Decrease in platelet number:
-Reduced production due to bone marrow problems
-DIC, autoimmune causes

Decrease function:
-NSAIDs, aspirin, renal failure, liver failure

Question 5

screening test for problem with primary haemostasis ?

Answer 5

check platelet count