Anti platelet drugs Flashcards

1
Q

MofA of aspirin?

A

Inhibits cyclo-oxygenase which is necessary to produce thromboxane A2 (a platelet agonist released from granules on activation)

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2
Q

SE aspirin?

A

-Bleeding
-Blocks production or prostaglandins – GI ulceration, bronchospasm

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3
Q

dual antiplatelet therapy- what?

A

aspirin + e.g. clopidogel or prasugrel

-used during high risk period
-patients won’t be on it for long

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4
Q

MofA Clopidogrel, prasugrel ?

A

ADP receptor antagonist

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5
Q

role of dipyridamole?

A

-Phosphodiesterase inhibitor
-increases cyclic AMP which as an effect to reduce platelet aggregation

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6
Q

life span of platelet and clinical relevance?

A

Anti-platelet drugs tend to affect platelet function for their 7-10 day life span

Stop anti-platelet agents 7 days prior to elective operations

If serious bleeding – can reverse with platelet transfusion

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7
Q

MofA of abciximab ?

A

GP 2a/3a inhibitor

inhibit aggregation – platelets attach to each other via GP2b3a and fibrinogen

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