Anti platelet drugs Flashcards
MofA of aspirin?
Inhibits cyclo-oxygenase which is necessary to produce thromboxane A2 (a platelet agonist released from granules on activation)
SE aspirin?
-Bleeding
-Blocks production or prostaglandins – GI ulceration, bronchospasm
dual antiplatelet therapy- what?
aspirin + e.g. clopidogel or prasugrel
-used during high risk period
-patients won’t be on it for long
MofA Clopidogrel, prasugrel ?
ADP receptor antagonist
role of dipyridamole?
-Phosphodiesterase inhibitor
-increases cyclic AMP which as an effect to reduce platelet aggregation
life span of platelet and clinical relevance?
Anti-platelet drugs tend to affect platelet function for their 7-10 day life span
Stop anti-platelet agents 7 days prior to elective operations
If serious bleeding – can reverse with platelet transfusion
MofA of abciximab ?
GP 2a/3a inhibitor
inhibit aggregation – platelets attach to each other via GP2b3a and fibrinogen