Presentation paper

Question 1

Paralogous proteins

Answer 1

Proteins within an organism that share sequence homology

Question 2

Paralogous protein example

Answer 2

Myoglobin and hemoglobin

Question 3

Protein specificity

Answer 3

How well a protein can distinguish between different sequences

Question 4

Specificity involves both

Answer 4

binding to a specific partner, and not binding to other proteins

Question 5

Many protein interaction domains in signaling proteins are members of

Answer 5

large paralogous families.

Question 6

Paralogous proteins arise through a process of

Answer 6

gene or domain duplication.

Question 7

Extant

Answer 7

Still in existance

Question 8

Phylogeny

Answer 8

Traced patterns of shared ancestry between lineages.

Question 9

Two-component signaling pathway

Answer 9

Signal transduction occurs through the transfer of phosphoryl groups from ATP to a specific histidine residue in the histidine kinase (HK).

Question 10

Kinase

Answer 10

An enzyme that catalyzes the transfer of a phosphate group from ATP to a specified molecule.

Question 11

Histidine kinases

Answer 11

Sensor proteins found only in prokaryotes.

Question 12

The specificity of the HK-RR interaction is determined primarily through

Answer 12

molecular recognition with a relatively small number of amino acids.

Question 13

Operon

Answer 13

a unit made up of linked genes which is thought to regulate other genes responsible for protein synthesis.

Question 14

ancHK

Answer 14

Last common ancestral proteins from which both EnvZ-OmpR paralogs descended.