PRES: Connectional Architecture: Brainnetome Atlas Flashcards

1
Q

What is the Brainnetome Atlas?

A

A connectivity-based atlas mapping the brain into 210 cortical and 36 subcortical regions.

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2
Q

What methods underpin the Brainnetome Atlas?

A

Multimodal neuroimaging, including structural, functional, and diffusion MRI.

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3
Q

How are connectivity-based parcellations determined?

A

By aggregating voxels with similar connectivity profiles.

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4
Q

What is a ‘connectional fingerprint’?

A

A unique pattern of brain region connectivity.

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5
Q

How does the atlas validate its parcellations?

A

Using split-half reliability and interhemispheric topographic consistency.

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6
Q

What imaging data supports connectivity mapping?

A

Probabilistic tractography and resting-state functional MRI.

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7
Q

How does the atlas integrate functional data?

A

By mapping behavioral tasks to specific brain regions.

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8
Q

What is the resolution of the Brainnetome Atlas?

A

It uses submillimeter resolution for detailed parcellations.

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9
Q

How does the atlas handle anatomical variability?

A

Through probabilistic maps reflecting interindividual differences.

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10
Q

What database aids functional characterization of regions?

A

The BrainMap database.

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11
Q

What are Maximum Probability Maps (MPMs) in this atlas?

A

Maps of the most probable location of subregions.

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12
Q

How does the atlas assist in understanding diseases?

A

By linking connectivity patterns to neurophysiological substrates of disorders.

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13
Q

What is the purpose of functional connectivity maps?

A

To reveal task-related activations and resting-state networks.

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14
Q

How is connectivity similarity assessed across hemispheres?

A

Using the cosine distance of connectivity fingerprints.

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15
Q

How are structural and functional connections compared?

A

By integrating probabilistic tractography and functional correlation maps.

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16
Q

What is the significance of parcellation clusters in the atlas?

A

They represent functional subdivisions within larger brain regions.

17
Q

What is the Brainnetome Atlas Viewer?

A

An interactive platform for exploring the atlas and its connectivity data.

18
Q

How does the atlas benefit cognitive neuroscience?

A

By providing a structure-to-function mapping of brain regions.

19
Q

What are the main challenges of creating the Brainnetome Atlas?

A

Capturing detailed connectivity while ensuring reproducibility.