Premidterm Vitamins/cofactors And Shit Flashcards
Copper
Needed for:
Lysyl oxidase (ECM)-(hydroxy)lysine to al(hydroxy)lysine of collagen for covalent cross linking.
Complex 4/cytochrome oxidase
Vitamin C
Cofactor for prolyl hydroxylase and lysyl hydroxylase (modify prepro-alpha chains of collagen). Deficiency causes scurvy.
B12
Needs intrinsic factor from parietal cell for proper absorption, otherwise pernicious anemia
B3
Niacin
Used to make NAD+
B2
Riboflavin
Used to make FAD
Thiamine
TPP
Aka B1
Used in PDH, aKgDH, branched chain fatty acid dehydrogenase, transketolase
Deficiency: Werner-korsakoff syndrome
(Alcoholics) down ATP, increased cardiac output(wet beri-beri) ataxia, cerebral hemorrhage
Lipoic Acid
PDH, aKgDH, branched chain fatty acid dehydrogenase
Effected by arsenic poisoning (E2)
PLP
Required by glycogen phosphorylase
B6
B7
Biotin
Used in pyruvate carboxylase