Drugs

Question 0

Azidothymidine AZT

Answer 0

Deoxythymidine analog phosphorylated by host cellular kinase used in HIV MECH: termination of DNA due to lack of 3’ OH

Question 1

Ciprofloxacin

Answer 1

Quinolone antibiotic inhibits bacterial DNA gyrase

Question 2

Didanosine (ddl)

Answer 2

Deoxyadenosine analog phosphorylated by host cellular kinase used in HIV mech: termination of DNA due to lack of 3’ OH

Question 3

Tenofovir

Answer 3

Deoxyadenosine-P analog phosphorylated by host cellular kinase used in HIV termination of DNA chain.

Question 4

Acyclovir

Answer 4

Deoxyguanisine analog used in HSV and VZV phosphorylated by VIRAL kinase termination of DNA due to lack of 3’ OH

Question 5

Cytosine Arabinoside (araC)

Answer 5

Deoxycytosine analog phosphorylated by host cellular kinase used in leukemia termination of DNA due to stereo restraint

Question 6

Adenosine Arabinoside (araA) (Vidarabine)

Answer 6

Deoxyadenosine analog phosphorylated by host cellular kinases used in HSV and Relapsed Childhood Acute Lymphoblastic Leukemia termination of DNA due to stereo restraint

Question 7

Decitabine (5-methyl-2’ deoxycytidine)

Answer 7

Deoxycytidine analog used in cancer causes inability of DNA methyltransferase to methylated 5’ N (removes suppression of P15 tumor suppressor gene)

Question 8

Camptothecin

Answer 8

Used in cancer inhibits topoisomerase I (affects cancerous and normal cells)

Question 9

Etoposide

Answer 9

Used in cancer inhibits topoisomerase II (affects cancerous and Normal cells)

Question 10

Actinomycin D (Dactinomycin)

Answer 10

Used in cancer and as antibiotic (developing countries) intercalated with DNA prevents replication and transcription

Question 11

Rifampin

Answer 11

Used in TB lock and key inhibitor of RNA polymerase of bacteria

Question 12

Diphtheria toxin

Answer 12

ADP-ribosylation of ef2 blocks termination and elongation

Question 13

Streptomycin

Answer 13

Amino glycoside distorts 30s ribosome prevents assembly, not used frequently (affects Eukaryotes)

Question 14

Tetracycline

Answer 14

Four rings block movement of aminoacyl tRNA prevents elongation antibiotic

Question 15

Erythromycin

Answer 15

Macrolide antibiotic binds to 50s ribosome, prevents movement and elongation

Question 16

Chloramphenicol

Answer 16

Inhibits prokaryotic peptidyl transferase activity of ribosome (may inhibit mitochondrial ribosomes)

Question 17

Cyclohexamide

Answer 17

Organic molecule used in labs inhibits eukaryotic peptidyl transferase

Question 18

Puromycin

Answer 18

Partial aminoacyl tRNA analog causes peptide to fall out of ribosomal P site, toxic to everything

Question 19

Allopurinol

Answer 19

Used for gout suicide inhibition of xanthine oxidase substrate analog binds to enzyme and interferes with molybdenum cofactor

Question 20

DFP (di-isopropyl fluorophosphate)

Answer 20

Nerve gas poison irreversible inhibitor of acetylcholinesterase

Question 21

Aspirin (N-Acetyl-salicilic acid)

Answer 21

Irreversible inhibitor of cox1 and cox2