Premature Ovarian Insufficiency Flashcards

1
Q

What is premature ovarian insufficiency?

A

menopause <40

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2
Q

What are causes?

A

Usually idiopathic
iatrogenic - surgery (oophorectomy)
chemo
radio

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3
Q

What are the natural causes

A

chromosome abnormalities

FSH receptor gene polymorphisms

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4
Q

How is a diagnosis made

A

FSH >25IU/l – 2 samples >4 weeks apart + 4 months of amenorrhoea,
must confirm menopause

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5
Q

why is FSH increased in POI

A

¥ No feedback of oestrogen to the pituitary so FSH just gets higher and higher

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6
Q

What is the management

A

Oestrogen replacement:
Ð HRT until 51
Ð COCP
Androgen replacement (mainly for libido) - testosterone gel

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