(Prelims) MedOrg Exam Pt.2

Question 1

First commercially successful SSRI?

Answer 1

Fluoxetine

Question 2

First pure hormone to be isolated from the endocrine gland

Answer 2

Epinephrine

Question 3

Thyroid hormones that regulate the body?

Answer 3

T4 - Tyrosine
T3 - Triiodothyronine

Question 4

Natural stress hormone produced by the body

Answer 4

Cortisol

Question 5

Steroid that mimics the action of Cortisol

Answer 5

Cortisone

Question 6

True or False:

Cortisol levels are higher when newly awake

Answer 6

True

Question 7

This person isolated thyroxine from the thyroid gland and discovered the activity of the cortisone

Answer 7

Edward Kendall

Question 8

Hormone produced by Pancreas

Answer 8

Insulin

Question 9

Regulates glucose level

Answer 9

Insulin

Question 10

Route of Administration of Insulin (also include the approved ROA in 2006)

Answer 10

SubQ and Inhalation

Question 11

FDA approved insulin-derived drug used to control blood sugar levels in combination with peptide hormone

Answer 11

Symlin

Question 12

Similar structure with progesterone and is abundant in yams

Answer 12

Diosgenin

Question 13

Known to stop ovulation in rabbits

Answer 13

Diosgenin

Question 14

Why can’t Diosgenin be formulated into a drug?

Answer 14

It is destroyed by the digestive system

Question 15

The first orally active contraceptive steroid which was a modification of the structure of Progesterone. Who synthesized this?

Answer 15

Norethindrone

Synthesized by Carl Djerassi

Question 16

True or False:

Norepinephrine + Progesterone is an effective oral contraceptive

Answer 16

False

NORETHINDRONE + Progesterone is an effective oral contraceptive

Question 17

The first combined orally active contraceptive. Who synthesized it?

Answer 17

Mestranol + Norethynodrel

Synthesized by John Rock

Question 18

Difference of Progesterone and Progestin

Answer 18

Progesterone = natural hormone produced by body
Progestin = drug created and available in the market

Question 19

Referred to as the abortion pill

Answer 19

RU-486 (Mifepristone)

90% effective for uterine contraction

Question 20

Initial use of Mifepristone

Answer 20

Glucocorticoid antagonist

Tx of Breast cancer, glaucoma, Cushing syndrome

Question 21

Also known as the morning after pill, referred to as an Emergency contraceptive

Answer 21

Levonorgestrel

Question 22

Levonorgestrel is taken with ___ hours of unprotected sex

Answer 22

72

Question 23

2 Hormones from the posterior pituitary gland, also give their uses

Answer 23

Vasopressin - exerts pressor and antidiuretic activity
Oxytocin - Lactation & Uterine motility